There is no chemical property that makes an aromatic compound masculine or feminine. The gender categories in commercial fragrance are not rooted in biology, chemistry, or psychology. They are a marketing architecture built in the 20th century — and they are dissolving because they were never load-bearing.
The gendered fragrance category system was formalised in the 1920s and consolidated through the mid-20th century, driven by the growth of mass-market fragrance and the need for retail categorisation. The conventions that emerged — woody, spicy, and leathery accords coded masculine; floral, powdery, and soft oriental accords coded feminine — were not derived from any physiological difference in how men and women perceive or respond to aromatic compounds. They were derived from contemporary gender marketing conventions and the aesthetic preferences of specific cultural moments. Chanel No.5, launched in 1921 and still the world's most recognised fragrance, was created with significant aldehyde and abstract accord content that broke from the floral soliflore conventions of its era — it was not feminine because of its chemistry. It was feminine because it was marketed to women.

THE INSIGHT
The chemistry of olfactory perception does not differ significantly between sexes. Studies of olfactory sensitivity, discrimination ability, and hedonic response to specific aromatic compounds show marginal population-level differences that are far smaller than the within-sex variation — meaning the range of olfactory responses within men is wider than the average difference between men and women. What does differ is learned association: the aromatic profiles that have been consistently paired with gender identity markers (packaging, advertising, cultural context) become associated with those markers through conditioning. The association is cultural, not chemical. Which is why it is changeable — and is visibly changing in the contemporary fragrance market.
TAKEAWAY
The relevant question when selecting a fragrance is not which gender category the bottle is marketed in. It is whether the formula performs correctly on your skin, whether the act structure suits your wear context, and whether the drydown becomes part of your identity. The gender label on a bottle communicates marketing convention. The chemistry of the formula communicates nothing about who should wear it.